Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers

Cancer incidence and mortality are increasing globally, leading to its rising status as a leading cause of death. The Go-Ichi-Ni-San (GINS) complex plays a crucial role in DNA replication and the cell cycle. The GINS complex consists of four subunits encoded by the GINS1, GINS2, GINS3, and GINS4 genes. Recent findings have shown that GINS2 expression is upregulated in many diseases, particularly tumors. For example, increased GINS2 expression has been found in cervical cancer, gastric adenocarcinoma, glioma, non-small cell lung cancer, and pancreatic cancer. It correlates with the clinicopathological characteristics of the tumors. In addition, high GINS2 expression plays a pro-carcinogenic role in tumor development by promoting tumor cell proliferation and migration, inhibiting tumor cell apoptosis, and blocking the cell cycle. This review describes the upregulation of GINS2 expression in most human tumors and the pathway of GINS2 in tumor development. GINS2 may serve as a new marker for tumor diagnosis and a new biological target for therapy.     

皮肤鳞状细胞癌的中医药治疗进展

皮肤鳞状细胞癌是具有发病率高、发展快、可转移、易误诊等特点的一种恶性肿瘤，对人类的健康造成威胁。随着中医的发展和现代医学实验研究技术的进步，中医药在皮肤鳞状细胞癌的现代研究方面也取得一定成果。目前临床上治疗鳞状细胞癌多采取手术及药物化疗等，因不良反应的存在，患者接受度低。中药具有多靶点、安全性高、不良反应少等优势，在治疗皮肤鳞状细胞癌中中医具有一定优势，本文将围绕中药单体、中药复方，以及针灸在治疗皮肤鳞状细胞癌的研究进展展开论述和思考。     

童年期不良经历对个体健康影响的研究进展

童年期不良经历(ACEs)作为一项全球性的严峻公共卫生挑战,其对全生命周期的健康影响不容小觑。因此本文从心理健康、生理健康、性传播疾病及危险性行为、健康危险行为4个方面对ACEs的健康影响进行综述,为ACEs及其可能健康结局提供参考。     

啤酒制造工人工作相关肌肉骨骼疾患及其影响因素分析

目的 调查啤酒制造工人工作相关肌肉骨骼疾患（WMSDs）的现状并探讨其影响因素。方法 采用流行病学横断面调查方法，选择广州市某大型啤酒制造厂501名啤酒制造工人为研究对象，应用中文版《肌肉骨骼疾患调查问卷》调查WMSDs的患病现状，采用多因素Logistic回归方法分析工人罹患WMSDs的影响因素。结果 啤酒制造工人WMSDs总发生率为39.7%（199/501），其中发生率较高的部位是颈部27.1%（136/501）、肩部25.0%（125/501）、下背部24.0%（120/501）、上背部23.2%（116/501）。啤酒制造工人罹患多部位WMSDs的比例为28.9%（145/501），单一部位发生率为10.8%（54/501）。多因素Logistic回归分析结果显示，与总工龄<5年者相比，工龄10～<15年的工人罹患WMSDs的风险增加（P<0.05）；吸烟≥20支/周、经常替同事上班者罹患WMSDs的风险增加（P<0.05）。结论 啤酒制造工人WMSDs患病风险较高，发生率较高的部位分别是颈部、肩部和下背部。啤酒制造行业应加强员工健康培训，注意对工龄较长员工的保护，宣传吸烟危害，合理安排工人轮休和作息，以降低工人罹患WMSDs的风险。     

Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression

Cancer has become the most life-threatening disease in the world. Mutations in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs, especially long noncoding RNAs (lncRNAs), have significant effects in human cancers. LncRNAs have no protein-coding ability but function extensively in numerous physiological and pathological processes. Small nucleolar RNA host gene 3 (SNHG3) is a novel lncRNA and has been reported to be differentially expressed in various tumors, such as liver cancer, gastric cancer, and glioma. However, the interaction mechanisms for the regulation between SNHG3 and tumor progression are poorly understood. In this review, we summarize the results of SNHG3 studies in humans, animal models, and cells to underline the expression and role of SNHG3 in cancer. SNHG3 expression is upregulated in most tumors and is detrimental to patient prognosis. SNHG3 expression in lung adenocarcinoma remains controversial. Concurrently, SNHG3 affects oncogenes and tumor suppressor genes through various mechanisms, including competing endogenous RNA effects. A deeper understanding of the contribution of SNHG3 in clinical applications and tumor development may provide a new target for cancer diagnosis and treatment.     

从《温疫论》浅谈调脾胃防治新型冠状病毒肺炎

新型冠状病毒肺炎(COVID-19)患者除呼吸道症状以外,常伴有纳差腹胀、大便不调等消化道症状,舌苔往往厚腻,有湿邪侵犯中焦的特点。中医认为脾胃与肺关系密切,手太阴肺经起于中焦,下络大肠,还循胃口,与脾共司水液代谢。同时从国家及各地区发布的COVID-19中医诊疗方案中也可看出,针对脾胃的治疗贯穿始终,与《温疫论》中的观点不谋而合,因此在治肺的基础上应当重视脾胃的治疗。结合《温疫论》中相关论述及现有的报道和临床资料,参照《新型冠状病毒感染的肺炎诊疗方案(试行第五版)》疾病分期,探讨从脾胃角度防治COVID-19。